New research from the Kennedy Institute has revealed how two important proteins, TBK1 and IKKε, play a crucial role in ...

Additionally, most cancer cells have developed various ways to escape immune surveillance. Nevertheless, novel anticancer strategies such as oncolytic viro-immunotherapy can trigger immunogenic cell ...

为探究 E3 泛素连接酶自身的翻译后修饰和稳定性，研究人员开展了关于 USP43 与 RNF2 关系的研究。结果发现 USP43 能稳定 RNF2，二者通过调控 TBK1 泛素化和降解影响抗病毒先天免疫，揭示了新的免疫调控机制。 摘要：E3 泛素连接酶通常调节底物蛋白的泛素化和降解 ...

但在 ALS 发病机制中，TBK1 基因功能缺失影响的众多途径尚未完全明确，且缺乏合适的体内模型来深入探究。为了填补这些空白，来自法国 Imagine Institute 等机构的研究人员开展了一项极具意义的研究，相关成果发表在《Cell Death Discovery》上。 研究人员运用了多种 ...

Ferroptosis is a novel form of cell death that uniquely requires iron and is characterized by iron accumulation, the generation of free radicals leading to oxidative stress, and the formation of lipid ...

When Wdr5 was disabled, the number of HSPCs dropped significantly, leading to widespread DNA damage and cell death. A key mechanistic insight is that Wdr5 reduces the accumulation of "R-loops ...

On Saturday, the Department of Corrections issued a statement confirming prison officials were notified of Thitisan's death on Friday around 8.30pm. He was found slumped against his cell door with ...

Mar. 26, 2025 — Researchers have developed 'tomoseqr' -- a new software tool that enables easy estimation of the three-dimensional (3D) spatial distribution of gene expression. Tomoseqr is free ...