However, studying these cells using single-cell RNA sequencing (scRNA) methods is tricky because the cells are delicate and can be damaged when taken out of their natural environment in the ...

The metrics are designed mainly for tissue images assuming that (1) there are multiple channels, and (2) there are multiple cell types that are expected to differ in their expression values for the ...

This work developed a new biochemical method that uncovered the function of a poorly characterized protein called calmin," said W. Mike Henne, Ph.D., Associate Professor of Cell Biology and ...

Particularly, whole-cell patch-clamp experiments would limit the target molecules to those acting externally, potentially overlooking molecules that act intracellularly. Additionally, our extraction ...

Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ ...

Reference: Haoran Chen and Robert F. Murphy (2023) 3DCellComposer - A Versatile Pipeline Utilizing 2D Cell Segmentation Methods for 3D Cell Segmentation. Under review. Changes in V1.3: Options added ...

Existing microfluidic-based single cell sequencing methods have limited cell and sample throughput making it hard to perform longitudinal studies to capture changes in TCR repertoire dynamics during ...

As part of the Cancer Dependency Map project we are working to develop approaches for relating cell lines to patient tumors. Here we demonstrate a simple supervised classifier inspired by ...