Applying LINMAP to a CRISPR-Cas9 lineage-traced lung cancer mouse model, we successfully traced tumors of varying clonality within ... It enables comprehensive single cell lineage tracing, providing ...

Lineage tracing allows us to follow the progeny of a single cell to better understand this evolution, including acquisition of genetic lesions, clonal outgrowth, and metastatic spread ...

UHN Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

Lineage Cell Therapeutics, Inc. (NYSE American and TASE: LCTX), a clinical-stage biotechnology company developing allogeneic cell therapies for unmet medical needs, and the Christopher & Dana ...

constitutive Notch1 signaling induces a basal-to-luminal cell fate switch in adult cells of the lacrimal gland, the salivary gland, and the prostate. Since the lineage transition is progressive in ...

We performed lineage tracing and transcriptomic analysis of Iqgap3 +isthmus stem cells with the Iqgap3-2A-tdTomato mouse model. Depletion of Iqgap3 revealed its functional importance in maintenance ...

1 Day LCTX 5.57% DJIA 1.23% Russell 2K 2.00% Health Care/Life Sciences -0.64% ...

The tardigrade’s unusual body plan and resistance to harsh conditions provide researchers like Bob Goldstein with a creative ...