这篇综述聚焦癌症免疫中 cGAS-STING 通路，深入剖析其激活免疫反应、发挥抗肿瘤作用的机制，探讨在癌症治疗中的应用、STING 激动剂的研发进展，分析面临的挑战，为癌症免疫治疗提供新思路，文章发表在《Journal of Hematology & Oncology 》上值得一读。 癌症免疫中的 ...

为探究 STX12 缺乏的病理生理改变及致死机制，研究人员构建 Stx12 基因敲除小鼠和敲低斑马鱼模型开展研究。结果发现 STX12 缺失导致线粒体损伤、mtDNA 释放，激活 cGAS-STING 通路和炎症反应，这为揭示相关疾病机制提供了新视角。

1 Department of Pulmonary and Critical Care Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China 2 Department of Thoracic Surgery, ...

Department of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan 430060, P. R. China ...

A conserved molecular pathway controlled by the proteins cGAS, STING and IRF3 can detect DNA outside of these compartments, and report it to the neighboring immune cells by secondary messengers ...

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China ...

"With the discovery and mapping of the cGAS-STING signaling pathway, the award winners have opened up completely new approaches to drug research," explains Thomas Boehm, Chairman of Paul Ehrlich ...