it halted progression at the S phase through the ATR/Chk1 pathway, while in HCT-116 cells, it caused arrest at the G1 phase via the ATM/Chk2 pathway. This was accompanied by downregulation of key ...

it halted progression at the S phase through the ATR/Chk1 pathway, while in HCT-116 cells, it caused arrest at the G1 phase via the ATM/Chk2 pathway. This was accompanied by downregulation of key ...

Ephraim’s complaint against Gideon; kings of Midian slain; Gideon’s children; his death; Abimelech made king: death of Abimelech. And Gideon said unto them, I will not rule over you, neither shall my ...

为探究缺氧肿瘤微环境中 HIF-1α 的调控机制，研究人员发现 ROS-ATM-CHK2 轴稳定 HIF-1α 促进肿瘤血管生成，为抗血管生成疗法提供理论依据。 在肿瘤的世界里，缺氧是一个极为常见且关键的 “角色”。肿瘤在生长过程中，随着体积不断增大，内部的细胞逐渐难以 ...

Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals. Existing ...

本研究聚焦胃癌化疗耐药难题，揭示ADAM9通过激活ATM-CHK2通路增强DNA修复，导致胃癌细胞对顺铂耐药，为克服化疗耐药提供新靶点 胃癌是全球最常见的恶性肿瘤之一，化疗耐药的发生严重影响中晚期患者的生存和预后。增强DNA修复能力是化疗耐药的重要机制之一。

After hours: March 24 at 7:42:57 PM EDT Loading Chart for ACRV ...

After hours: March 21 at 7:53:26 PM EDT Loading Chart for CMPS ...