A new Drosophila collection of Parkinsonism models reveals early synaptic cholinergic projection neuron dysfunction, linking synaptic failure to later dopaminergic decline, highlighting a role for ...

The authors found that cholinergic olfactory projection neurons (OPN) were consistently affected across the fly models, showing synaptic dysfunction before the onset of motor deficits, known to be ...

This article examines the existing scientific applicability of the original cholinergic hypothesis of Alzheimer’s disease by describing the biochemical and histopathological changes of ...

An evolutionarily conserved micropeptide, Sertm2, encoded by the lncRNA A730046J19Rik, promotes Etv4 + motor neuron subtype specification by GDNF, proper neurite development, and motor function.

Specialised intestinal macrophage subsets appear to receive cues from surrounding cells, a concept otherwise known as macrophage niche. Neuron-associated macrophages are crucial for the survival and ...

First, the neuropathological state of AD resulting from synapse loss is mimicked by decreasing the synaptic connectivity strength from the Inter-Neurons (IN) neuron population to the Thalamic Relay ...

Nicotinic receptor signaling is influential in modulating appropriate responses to salient stimuli within a complex environment. The cholinergic neurotransmitter system drives attention to salient ...

Apr. 9, 2025 — Heavy drinkers who have eight or more alcoholic drinks per week have an increased risk of brain lesions called hyaline arteriolosclerosis, signs of brain injury that are ...

Backed Natural Formula Designed to Enhance Memory, Boost Focus, and Support Long-Term Cognitive Health.Denver, April 03, 2025 ...