2005). Histone sequences are highly conserved. The diagram in Figure 2 shows a typical chromatin fiber, with the blue cylinders representing histones. Extending from each of the histones is a ...

Most cells in the human body each contain about six feet of DNA. Yet the nucleus, where DNA is coiled, is no larger than a ...

In the study, investigators utilized nanoscale imaging and sensing technologies along with modeling techniques developed at Northwestern to individually label and observe chromatin fibers ...

This experiment demonstrated that H2A, H2B, H3, and H4 form a discrete protein octamer, which is fully consistent with the presence of a repeating histone-containing unit in the chromatin fiber.

In eukaryotes, genomic DNA is stored in the nucleus as nucleosomes, interacting with a set of proteins, forming a molecular complex called chromatin. The proper folding of the chromatin structure ...

Northwestern Medicine scientists have uncovered new details about the genetic structure of ovarian cancer stem cells, according to a study published in Advanced Science. Inside cells, DNA mixes ...