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Understanding how RNA folds into functional structures requires methods that can systematically assess how sequence perturbations affect RNA structure and function. Here, the authors develop a ...

Get Instant Summarized Text (Gist) A computational tool named NuFold has been developed to model 3D RNA structures, potentially accelerating medical discoveries by decades. This tool addresses the ...

RNA vaccines are composed of the nucleic acid RNA, which encode antigen genes of an infectious agent. When administered to host cells, the RNA is translated into protein antigens that elicit ...

这为理解疾病机制、开发诊断和治疗方法提供新思路，值得科研读者阅读。 神经系统疾病中的环状 RNA：计算识别、功能验证及潜在临床应用 奥克?哈齐马诺利斯，亚历克斯?M?赛克斯，亚历山大?S?克里斯蒂诺? Crown 2025 近年来，随着生物技术的进步，尤其是高通量 ...

肺癌，这一全球范围内严重威胁人类健康的 “杀手”，其发病率和死亡率长期位居癌症前列。尽管近年来针对特定基因产物的药物发展为肺癌治疗带来了新的曙光，但患者的预后情况依旧不容乐观。在探索肺癌奥秘的征程中，研究人员发现了一类特殊的 RNA—— 环状 RNA（circRNA），它在肿瘤的发生发展中扮演着重要角色。同时，8 - 氧鸟嘌呤（o8G）修饰对 RNA 命运的调控作用也逐渐浮出水面，可 ...

“In general, we have not recommended boosters because there is no clear evidence that people need it. But there probably is ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts. RNA splicing is a cellular ...