pharmaphorum3d
FDA gives AbbVie's c-Met lung cancer ADC a breakthrough tag
The c-Met protein thought to be both a driver of cancer ... in patients both with and without other gene mutations including EGFR and ALK. Other drugmakers have been looking at Met as a target ...
pharmaphorum1y
AbbVie cues up filing for c-Met ADC in lung cancer
The c-Met protein is thought to be both a driver of ... in patients both with and without other gene mutations, including EGFR and ALK. The drug is furthest along in development among AbbVie ...
Nature12y
The short form of RON is expressed in acute myeloid leukemia and sensitizes leukemic cells to cMET inhibitors
cMET/RON inhibitors exhibited an antileukemic activity exclusively in AML samples and cell lines expressing sfRON. These results might support clinical trials evaluating cMET/RON inhibitors in AML ...