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LCN2:脓毒症相关认知障碍的关键 “推手” 与潜在治疗靶点
免疫荧光实验显示,下调 LCN2 能恢复 LPS-ACM 处理导致的溶酶体标记物 Lamp2 和线粒体标记物 Tomm20 共定位减少,同时逆转 LPS-ACM 处理导致的 Pink1 水平降低。这表明 LPS 诱导的 SAE 可能是由于 LCN2 介导的线粒体损伤,而下调 LCN2 可能通过恢复线粒体功能来挽救 SAE。
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