Not everyone with ADHD responds to stimulants like Ritalin, which increase dopamine levels in the brain. Now, new research ...

The highly selective partial agonist at D1 and D5 receptors significantly improves motor function in patients recently ...

Here, the authors report a modular click ligand-directed approach to covalently attach fluorescent dyes to endogenous dopamine D1 receptors in live cells. CXCR3 and CXCR7 are chemokine receptors ...

A new pill, tavapadon, has shown potential in easing Parkinson’s symptoms while limiting side effects. In patients taking at ...

"Instead, we found the types of dopamine receptors on the brain cells, and the ratio in which they are found, better predicted cognitive performance." Study participants who had a higher ratio of ...

The study specifically examines two types of GPCRs expressed on astrocytes: dopamine D1 receptors (D1R) and metabotropic glutamate receptor 5 (mGLUR5). These receptors respond to various ligands, ...

1995; Yasuda et al. 1988). Instead, both OPC-14597 and OPC-4392 exhibit clear antagonist actions at postsynaptic receptors, as evidenced by inhibition of apomorphine-induced stereotypy and ...

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

In the study, Tavapadon, which works by mimicking dopamine and targeting the D1/D5 receptors, was found to have the same benefits as levodopa without the adverse effects, according to Hubert H.