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创新方法精准定位低序列复杂性蛋白结构域中关键区域,解锁细胞奥秘
本文聚焦低序列复杂性蛋白结构域(LCD),开发出一种简单分子生物学方法,可定位其自缔合、相分离关键区域,以 TDP - 43 蛋白为例精准锁定关键序列,有助于理解相关疾病机制,推动该领域从实验向计算机模拟发展。
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