so histones bind with DNA very tightly. The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA ...

They interact with proteins, RNA, and chromatin DNA to exert their functions. Therefore, an efficient and straightforward experimental approach that simultaneously captures the interactions of ...

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells - ...

As our bodies grow, cells proliferate to form tissues, and cells frequently have to be repaired or replaced throughout life..

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

This article explores 6-base genome sequencing and how it is empowering researchers to expand their studies to include both ...

In the pursuit of understanding the pathogenic expression mechanisms of bacteria and the advancements in biofoundry ...

Human cells divide daily. Every time, they must duplicate both their DNA and the structure that contains it. Chromatin, the name for this packaging, serves as a guide. It instructs the cell on ...

New research illustrates how a DNA repair protein suppresses senescent cells, reducing age-associated chronic inflammation.

The enriched chromatin sample was decrosslinked and released from Protein G beads by incubation with proteinase K (Thermo Fisher, AM2548) at 65°C overnight. Tn5 tagmentation (Vazyme, TD501-01) was ...

Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...