DNA methylation and histone modification influence each other during development. Histone methylation can help to direct DNA methylation patterns, and DNA methylation seems to serve as a template ...

The basic building blocks of chromatin are nucleosomes, each of which is composed of 146 bp of DNA wrapped around a histone octamer that consists of two copies each of H2A, H2B, H3 and H4.

Researchers at the University of Cologne have found that mRNA-based COVID-19 vaccines have a lasting impact on the innate ...

Northwestern Medicine scientists have uncovered new details about the genetic structure of ovarian cancer stem cells, ...

In a preprint uploaded to bioRxiv this January that has yet to undergo peer review, the team describes hundreds of potential histone proteins in bacteria, including one that they predict interacts ...

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I ...

They discovered that despite relatively weak binding by an essential protein—histone variant CENP-A/Cse4—to DNA, other proteins are recruited to one specific site in the center of the chromosome ...

The basic organizational unit of the genome is a nucleosome, which is a short segment of DNA wound around a complex of eight histone subunits. Each of these histones has a tail region which can be ...

Small chemical modifications can be added to histones, which allow proteins to access the tightly bound DNA from their histone bookcases to turn "on" and "off" genes in the organism. With ready ...

These minichromosomes bind with histone and nonhistone proteins, becoming transcriptionally active and sustaining viral replication. Key epigenetic mechanisms—such as DNA methylation, histone ...

To compact the DNA, plants use various epigenetic marks, including DNA methylation and modifications of the histone proteins that organize and package the DNA. These two marks reinforce each other ...