Immunoprecipitation of histone deacetylase activity from cell ... Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915–926 (1992).

They discovered that despite relatively weak binding by an essential protein—histone variant CENP-A/Cse4—to DNA, other proteins are recruited to one specific site in the center of the chromosome ...

该肽段通过与 DNA 及其他组蛋白相互作用，维持染色质的基本结构和稳定性 ... 参与如阿尔茨海默病、帕金森病等疾病的病理过程。 Histone H3 (1-21) peptide：是组蛋白 H3 更短的 N 端肽段，同样包含一些关键的修饰位点，在研究组蛋白修饰的基本机制及与特定蛋白 ...

Schematic representation of histone-modifying factor recruitment on cccDNA minichromosomes in relation to viral protein HBx. GA, UNITED STA ...

AC, acetylation; HDAC2, histone deacetylase 2; HIF-α, hypoxia-inducible factor 1-alpha; RCC, renal cell carcinoma; TGF-β, transforming growth factor-beta; TNF-α, tumor necrosis factor-alpha; VEGF, ...

Histone modifications have been shown to play a role in chromatin packing and accessibility, nucleosome mobility, gene expression, and chromosome arrangement. In this review, we critically evaluate ...

Histone H4 (2-21) 是一组与单纯疱疹病毒1 (HSV-1) 基因组染色化相关的核心组蛋白。 核小体组装：Histone H4 是核小体的核心组成部分，与 DNA 结合形成染色质结构，调控基因的表达、DNA 修复和复制。 翻译后修饰：Histone H4 的 N 端区域（包括 2-21 片段）常发生多种翻译后 ...

Cellular aging involves growth arrest and epigenetic alterations, offering insights into therapeutic approaches for enhancing ...

Ring-shaped extrachromosomal DNA is implicated in many cancers. Rachel Brazil talks to the scientists trying to uncover their ...

A research team led by Dr. Li Yunhai from the Institute of Genetics and Developmental Biology of the Chinese Academy of ...

Epigenetic mechanisms are essential for the temporal and tissue-specific control of DNA transcription in various cell types (Pal and Tyler, 2016; Paluch et al., 2016). For instance, the acetylation of ...