The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...

However, current methods like DNA ligase-linked hydrogels present many challenges, including potential allergic reactions and complex administration procedures that limit clinical applications.

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

However, current methods like DNA ligase-linked hydrogels present many challenges, including potential allergic reactions and ...

During the DNA damage response (DDR), repair proteins such as the E3 ubiquitin ligase BRCA1 accumulate at DNA double-stranded breaks (DSBs), and ubiquitylation at these sites helps recruit further ...

In one model, DNA damage induces demodification of SUMOylated Mdm2, possibly by enhancing as-yet-unidentified Mdm2–SUMO isopeptidases or by inhibiting Mdm2-specific E3 ligases for SUMO.