DNA methylation is the covalent addition of methyl groups to DNA bases, typically the cytosine of CpG dinucleotides. It is catalyzed by methyltransferase enzymes using a S-adenosyl methionine ...

Certain DNA sequences can form structures other than the canonical double helix. These alternative DNA conformations—referred ...

You will be redirected to our submission process. DNA methylation is a key factor in the regulation of organismal development and tissue homeostasis. DNA methylation marks indicate how to regulate ...

A new study reveals that “methylation entropy”—the randomness of chemical tags on DNA—can accurately predict biological age and offers insights beyond traditional epigenetic clocks. By analyzing DNA ...

This method focuses on how random certain chemical tags on DNA become over time. The team compared this new measurement, called methylation entropy, to existing methods and found it performed just ...

In their quest to decipher the molecular mechanisms of sperm function in Marchantia, Feng and her team distinguished two waves of extensive DNA methylation during sperm development. These two waves ...

Epigenetic reprogramming holds promise for reversing aging, addressing cellular aging mechanisms and paving the way for ...

The distinction between biological and chronological age is vital for risk assessment and interventions aimed at enhancing longevity and quality of life.

Longitudinally measuring and forecasting changes in DNA methylation can reveal patterns of ageing and disease progression, but biosamples may not always be available. We introduce a probabilistic ...

Epigenetic changes in the placenta may shape how the fetal brain develops and thus influence the risk of psychiatric ...