Promoter sequences are DNA sequences that define where transcription of a gene by RNA polymerase begins. Promoter sequences are typically located directly upstream or at the 5' end of the ...

In the first step, repressor molecules induced by differentiation cues bind to the gene promoter region and turn off transcription. This form of repression seems to be completely reversible once ...

Genetic engineering in non-human primates has long been limited by the need for virus-based gene delivery methods. Recently, ...

Transgenic animals continue to play an essential role in many aspects of zebrafish research, including the development of disease models. The most widely used system for zebrafish transgenesis is the ...

Researchers at University of Tsukuba have developed a vector that integrates the Cre enzyme gene with the specific DNA ...

A new study published in PLOS Genetics has identified an extreme mutational hotspot within the genome of Pseudomonas ...

There is no discernable significant homology between human and either chicken or zebrafish insulin promoters, which is in keeping with the view that most human DNA is not alignable to species ...

While previous research had described bidirectional promoters in eukaryotes, as well as in a few bacteria and archaea species, the new study establishes divergent transcription—the reading of genes in ...

Researchers have engineered yeast to efficiently convert methanol into D-lactic acid, a key compound for biodegradable plastics and pharmaceuticals. By optimizing gene and promoter combinations, they ...

Just like other transcription factors, HSF5 binds to DNA promoters to regulate gene expression. What distinguishes HSF5 is its unique target specificity. The research revealed that the DNA motif ...

Chinese scientists have uncovered two major genes responsible for sorghum's double-grain spikelet, which dramatically enhance grain number and crop yield. A substantial 35.7-kilobase intrachromosomal ...