How do we find out which protein works in a particular DNA repair pathway? We know that if a DNA repair gene is mutated, cells become more sensitive to DNA damaging agents. Researchers in the ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...

A research team has unveiled a crucial mechanism that helps regulate DNA damage repair, with important implications for improving cancer treatment outcomes. The result was published in Cell Death ...

Scientists have long known that more than 500 genes (out of approximately 20,000 human protein-coding genes) are crucial for DNA repair. By comprehensively analyzing the interactions of these ...