TAg expression and viral replication occurred after the first round of host DNA replication, and TAg expression also depended on the cell's going through a first round of replication. If Needham ...

We show that saccharin mediates its antimicrobial activity via bulge-mediated cell lysis rather than through impacting DNA replication dynamics. We reveal that saccharin can inhibit a range of ...

Human life starts as a single cell that divides numerous times to create an entire human body consisting of trillions of cells. To maintain genome stability, cells need to faithfully replicate their ...

More information: Reuben Franklin et al, Histone chaperones coupled to DNA replication and transcription control divergent chromatin elements to maintain cell fate, Genes & Development (2025). DOI ...

Deoxyribonucleic acid (DNA) replication is fundamental to life, yet the precise mechanics of how helicases unwind the genome for replication remain unclear. A recent study published in Nature used ...

The yeast RGG motif-containing RNA binding protein Scd6 and its human ortholog LSM14A regulate the translation of specific ...

Replication stress ... such as those that mediate DNA repair and cell-cycle checkpoints, can also contribute to an unstable genome. A gene that encodes an RNA or protein that can directly or ...

The new perspective involves a basic dichotomy: The human genome is about six feet long when the DNA is stretched end to end, but it must fit into the nucleus of a cell, which is 80 times smaller ...

Biotech firms are engineering smarter, safer gene delivery systems to enhance the safety and efficacy of genetic medicines.

The risk of cancer goes up with age, in part because aging impedes the body's ability to detect and destroy cells with ...