Four different DPP-4 inhibitors (LAF237/vildagliptin, VP, Syrrx106124, and TP8211) acutely lower blood glucose and enhance glucose-stimulated insulin secretion in wild-type mice and in mice with ...

Sitagliptin selectively inhibits the action of DPP-4, the primary enzyme degrading the incretin hormones, allowing glucagon-like peptide-1 and glucose-dependent insulinotropic peptide to ...