De Duve named these new organelles "lysosomes" to reflect their lytic nature. That same year, Alex Novikoff from the University of Vermont visited de Duve´s laboratory. An experienced ...

The lysosomal peptidase lysosome family plays an important role in the immune escape process of glioma, which mainly includes aspartic acid cathepsin, serine cathepsin, asparagine endopeptidases, and ...

National Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China ...

EXCLUSIVE: Democratic lawmakers would not provide a definition of a woman when pressed on Capitol Hill, as President Donald Trump prioritizes making clear distinctions between biological sexes ...

Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea Department of Biosystems and Bioengineering, KRIBB School of Biotechnology, ...

Eight Irish English, or Hiberno-English, words that are "untranslatable" or "cannot be translated into another" are included in the Oxford English Dictionary's (OED) March 2025 update.

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Myeloperoxidase and proteinase 3, the targets of MPO- and PR3-ANCA, respectively, are both found in neutrophil granules and monocyte lysosomes. PR3 is normally expressed on the neutrophil ... limited ...

Suppressing KCTD20 in both the organoids and mice prevented glutamate from triggering tau accumulation and neurodegeneration. Further experiments showed that blocking this gene’s activity activated ...

Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to ...