Patrick Dempsey sure made the most of his McDream role on Grey's Anatomy. Dr. Derek Shepherd is one of the most enduring characters is TV history. Check out some of our favorite memories to see why!

Granted, there are plenty of heartbreaking deaths, fraught relationships, and traumatic backstories, but the love story that developed between Derek Shepherd (Patrick Dempsey), aka McDreamy ...

Meredith Grey, the protagonist of Grey's Anatomy, has won fans' hearts as she faced life's trials with resilience, intelligence, and emotional depth.

Throughout the series, Grey's Anatomy has introduced memorable characters, including Cristina Yang, Derek Shepherd, and Miranda Bailey among many others. Having more than 20 seasons, Grey's Anatomy ...

From the original show title to the real reason for certain character casting, here are 20 pilot details to celebrate 20 years.

This episode is also packed full of shocking revelations ... and he even went as far as to sue Derek Shepherd and the ...

Television titan Shonda Rhimes knew what she had just created — but audiences still had no idea. The Grey’s Anatomy pilot ...

Derek Shepherd: It's a beautiful day to save lives ... that one day they will open their eyes and it will come true. Katie Bryce: My head is full. Dr. Meredith Grey: It's called thinking. Go with it.

Sometimes, you walk into a shelter and you know exactly what you came there for. Whether you went there looking for one specific dog or you walk in and they're the one you find there, you just know ...