Scientists have designed new drug frameworks that selectively target CYP3A4, one of the most critical CYP proteins.

Grapefruit can affect the functioning of many different medications,” Emily Van Eck, MS, RDN, an Austin-based dietitian ...

Brian Tait, Chief Scientific Officer at Haplomic Technologies Pty Ltd, focuses here on CYP genes, haplotypes, and their ...

The drug is cleared by cytochrome P450 (CYP)3A4 metabolism. Peak plasma concentrations are achieved about 1.5 hours after oral administration. Its absorption is not affected by food. Eplerenone ...

Bayer today announced that the U.S. Food and Drug Administration (FDA) has granted full approval for VITRAKVI® (larotrectinib), a first-in-class TRK inhibitor for the treatment of adult and pediatric ...

在药物联用引发的药物相互作用问题日益凸显的背景下，研究人员开展了针对细胞色素 P450（CYP）3A4 选择性抑制剂的研究。他们通过高通量筛选等手段，发现了一系列选择性 CYP3A4 抑制剂，并揭示了其选择性抑制的机制，为设计更优的抑制剂提供了指导。

X-ray crystallography is a technique that uses X-ray diffraction patterns to determine high-resolution, three-dimensional structures of molecules such as proteins, small organic molecules, and ...

华大基因全新推出的药物基因检测产品，专为癫痫、精神分裂症、抑郁症和焦虑症患者打造 。通过采集受检者外周血样本，采用飞行时间质谱技术对药物相关基因多态性进行精准检测，基于国际权威药物基因组学研究证据，生成涵盖药物选择、剂量调整及风险预警的个体化用药方案 ...