And what about grapefruit juice versus chunks of the actual fruit? Below, we break down everything you need to know ...

Scientists have designed new drug frameworks that selectively target CYP3A4, one of the most critical CYP proteins.

Cytochrome P450 (CYP) proteins are responsible for breaking down more than 80% of all Food and Drug Administration ...

The drug is cleared by cytochrome P450 (CYP)3A4 metabolism. Peak plasma concentrations are achieved about 1.5 hours after oral administration. Its absorption is not affected by food. Eplerenone ...

Drug abusers. Renal or hepatic impairment ... reduce effects and/or precipitate withdrawal symptoms. Potentiated by CYP3A4 and CYP2D6 inhibitors (eg, macrolides, azole antifungals, protease ...

Potentiated by CYP3A4 inhibitors (eg ... Monitor for hypokalemia with potassium-depleting drugs (eg, amphotericin B, diuretics). Toxic epidermal necrolysis possible with thalidomide.

Drug screening is the process by which potential drugs are identified and optimized before selection of a candidate drug to progress to clinical trials. It can involve screening large libraries of ...

Naldemedine was safe and effective and reduced health care resource utilization among adults with opioid-induced constipation and chronic noncancer pain.