The junction protein E-cadherin plays a significant role in the intercellular force transmission in epithelia. It contributes to cells attaching themselves to each other (cell adhesions) while ...

Northwestern Medicine investigators have uncovered new insights into how intercellular "glue" functions to enable ...

Cells are in constant competition with each other and so eliminate diseased or unwanted cells. Cell competition is therefore a central principle for maintaining the health of tissues and organs.

New research challenges the classical interpretation of cell competition, revealing the importance of mechanical force.

These physical signals are determined by the strength of intercellular contacts, the E-cadherin junctions. Moreover, they showed that cells are extruded either apically or basally into the tissue ...

One of the major constituents of the cell-adhesion complex in epithelial cells is E-cadherin, a transmembrane protein involved in homotypic cell–cell adhesion. E-cadherin exerts a potent ...

E-cadherin is a transmembrane glycoprotein involved in epithelial cell adhesion. In cancer, downregulation of this protein enhances tumor cell dissociation, thereby increasing the risk of ...