Bin Xie and Shipeng Xu, graduate students in biophysics and biomedical engineering at the University of California, Davis, with Professor Sanjeevi Sivasankar, carried out a series of experiments to ...

More information: Bin Xie et al, Outside-in engineering of cadherin endocytosis using a conformation strengthening antibody, Nature Communications (2025). DOI: 10.1038/s41467-025-56478-6 Journal ...

P-cadherin is a protein commonly found on malignant cancer cells and has been used as a target for antibody-based cancer treatments. UC Davis biomedical engineers have discovered that when an antibody ...

The researchers found that when the anti-cancer antibody binds to P-cadherin, it locks it into the X-dimer form. The stable X-form then triggers a chemical signal that causes that patch of ...