More information: Bin Xie et al, Outside-in engineering of cadherin endocytosis using a conformation strengthening antibody, Nature Communications (2025). DOI: 10.1038/s41467-025-56478-6 Journal ...

Bin Xie and Shipeng Xu, graduate students in biophysics and biomedical engineering at the University of California, Davis, with Professor Sanjeevi Sivasankar, carried out a series of experiments to ...

P-cadherin is a protein commonly found on malignant cancer cells and has been used as a target for antibody-based cancer treatments. UC Davis biomedical engineers have discovered that when an antibody ...

The researchers found that when the anti-cancer antibody binds to P-cadherin, it locks it into the X-dimer form. The stable X-form then triggers a chemical signal that causes that patch of ...

Additionally, ER cells showed increased cell-cell adhesion, linked to upregulated E-cadherin. E-cadherin was found to be vital for erlotinib resistance, largely independent of GRHL2, highlighting ...

This research was funded in part by the BC Yukon Breast Cancer Foundation to David Huntsman and by the Breast Cancer Research Foundation (BCRF) to Judy E Garber. Serena Masciari is supported by a ...

Bin Xie and Shipeng Xu, graduate students in biophysics and biomedical engineering at the University of California, Davis, with Professor Sanjeevi Sivasankar, carried out a series of experiments to ...