Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of ...

Using this method and as a proof of principle, the researchers identified new targets of E3 ligases, RAD18 and CHIP, which are involved in cancer and neurodegenerative diseases, respectively.

DelveInsight's Molecular Glues Market Insights report includes a comprehensive understanding of current treatment practices, ...

However, the power of PROTACs lies in the engagement of E3 ligases, and currently, less than two percent of the vast array of E3 ligases in the human genome have been explored in the TPD field. Dr.

The ubiquitin E3 ligases are known to have pleiotropic functions through targeting several substrates and thereby affecting several regulatory pathways. We therefore set out to screen their gene ...

Proxygen GmbH has divulged molecular glue degraders comprising a cullin-ring E3 ligase (CRL)-binding moiety acting as cyclin-dependent kinase 12 (CDK12)/cyclin K degradation inducers reported to be ...

Professor Zoran Rankovic’s group is developing PROTACs, Molecular Glue Degraders, and E3 ubiquitin ligase chemical probes to study cancer biology and develop novel cancer drugs. Our group's research ...