They also found EGFR in the active conformation and wondered why this conformation seemed to be favored when crystallized (Zhang et al. 2006). They found that by mutating a residue in the kinase ...

EGF receptor (EGFR) tyrosine kinase inhibitors (TKIs), given their low molecular weight, may be able to reach a higher concentration in brain tissues. Various reports and small studies ...

The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?

WBRT and systemic treatments (chemotherapy and/or EGFR TKIs) are the treatment options for polymetastatic involvement of the brain. Treatment approaches are not influenced by the timing of onset ...

Lutris Pharma, a clinical stage biopharmaceutical company focused on improving anti-cancer therapies by reducing cutaneous ...