They also found EGFR in the active conformation and wondered why this conformation seemed to be favored when crystallized (Zhang et al. 2006). They found that by mutating a residue in the kinase ...

Lutris Pharma, a clinical stage biopharmaceutical company focused on improving anti-cancer therapies by reducing cutaneous dose limiting toxicity, today announced the upcoming presentation of the ...

The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?

WBRT and systemic treatments (chemotherapy and/or EGFR TKIs) are the treatment options for polymetastatic involvement of the brain. Treatment approaches are not influenced by the timing of onset ...

Researchers from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences and the Shanghai Institute of Organic Chemistry have divulged EGFR (L858R/T790M/C797S triple mutant) and ...

EGF receptor (EGFR) tyrosine kinase inhibitors (TKIs), given their low molecular weight, may be able to reach a higher concentration in brain tissues. Various reports and small studies ...