The researchers have discovered that in obese patients and in mouse models, increased levels of the oxidative enzyme myeloperoxidase ... suggest that targeted inhibition of MPO may be a promising ...

Angiotensin-converting enzyme (ACE) inhibitors are oral medications that lower blood pressure. They are used to treat a variety of heart-related conditions including high blood pressure, coronary ...

University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ ...

A research team has discovered that the enzyme myeloperoxidase (MPO ... The results suggest that targeted inhibition of MPO may be a promising new therapeutic approach for people with obesity ...

For instance, inhibitors that sensitized cells strongly for poly(ADP-ribose) polymerase (PARP) inhibition 24, or selective requirement of a kinase in a certain cancer type, have been recognized by ...

Multi-modal data integration of single-nuclei RNA and ATAC sequencing with spatial transcriptomics, provides new molecular insights into gene regulatory networks driving cell state transitions in ...