The researchers have discovered that in obese patients and in mouse models, increased levels of the oxidative enzyme myeloperoxidase ... suggest that targeted inhibition of MPO may be a promising ...

Angiotensin-converting enzyme (ACE) inhibitors are oral medications that lower blood pressure. They are used to treat a variety of heart-related conditions including high blood pressure, coronary ...

In addition, the clopidogrel acyl-glucuronide metabolite is a known strong time-dependent inhibitor of CYP2C8 leading to marked clinical DDIs with the substrates of this enzyme. Patients on ...

In using nojirimycin derivatives as glycosidase inhibitors, a large dose of the compounds is required to secure an effective endoplasmic reticulum lumenal concentration to eliminate the enzyme ...

University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ ...

A research team has discovered that the enzyme myeloperoxidase (MPO ... The results suggest that targeted inhibition of MPO may be a promising new therapeutic approach for people with obesity ...

The ELLA NA inhibition graphs of these pooled sera are shown in Supplementary Fig ... The mSN1 and the N1/19 hybrid both induced strong inhibitory antibodies to themselves, but the sera to mSN1 failed ...