3.5 Validation of PANoptosis and epithelial cellular responses in human CD samples In surgically resected intestinal specimens from patients with CD, IHC revealed that the expression of apoptosis ...

The epithelial–mesenchymal transition is the process by which polarised epithelial cells that are connected via adhesion lose their characteristics and acquire migratory and invasive properties ...

Moreover, pyroptosis-related proteins (Caspase-1, IL-1β, GSDMD) were significantly reduced after physcion treatment. Interestingly, the diversity of intestinal bacteria and the abundance in physcion ...

Atherosclerosis is a chronic inflammatory condition and a known risk for the development of cardiovascular diseases. In animal models of atherosclerosis, macrophage pyroptosis is linked to the ...

Get Instant Summarized Text (Gist) Epithelial cells, previously thought to be silent, have been found to communicate using slow electrical signals, similar to nerve impulses but 1,000 times slower ...

Host cells activate cell death pathways in response to bacterial manipulation of innate immune signalling, but the molecular ...

为探究 Calpain-1 在细胞焦亡中的作用及开发检测工具，研究人员利用 HyCoSuL 方法设计了 Calpain-1 特异性工具，发现其可与焦亡标记物共定位并能直接切割 GSDMD，为解析蛋白酶在细胞死亡中的作用提供了平台。 钙蛋白酶 - 1（Calpain-1）是一种依赖钙的半胱氨酸蛋白酶 ...

This barrier has a central role in regulating the controlled interaction between luminal factors and the intestinal immune system. Disruptions of intestinal epithelial cells, which serve as a physical ...

本期推荐：中南大学湘雅二医院团队发现PRDM16/USP10轴通过抑制NLRP3-Caspase1-GSDMD和Caspase3-GSDME通路缓解横纹肌溶解相关AKI，血小板 ...

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union ...