Figure 1e shows pathways with the highest contribution to prediction of drug synergy of the Capivasertib + Sapitinib combination: these include the ERBB-related pathways (ERBB2 signaling pathway, ERBB ...

The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes ...

Whole cell proteomics showed corresponding upregulation of chemokine signaling and NK-cytotoxicity pathways in CAR-CIK cells. In NSG mice xenografted with ErbB2+ RMS, a single injection of either ...

In human PDAC, high expression of SOX9 correlates with expression of genes belonging to the ERBB pathway. In particular, ERBB2 expression in PDAC cell lines is stimulated by SOX9. Inactivating Sox9 ...

Whenever we experience victories in life, we must never forget that Satan will tempt us to sin as he tempted David. Nathan's parable and David's repentance; birth of Solomon. And Uriah said unto David ...

Tissue fibrosis represents an aberrant repair process, occurring because of prolonged injury, sustained inflammatory response, or metabolic disorders. It is characterized by an excessive accumulation ...

Mouse gastric cancer organoid cultures were generated carrying molecular subtype-specific alterations. Conclusion We generated human and mouse gastric cancer organoids modelling typical ...

Alberta is launching the Class 1 Learning Pathway to enhance safety in the commercial driving industry and attract and retain drivers. Alberta is leading the way in Class 1 driver training and ...

Estrogen effects in tissue are mediated in part through activation of the surface estrogen receptor G protein–coupled estrogen receptor (GPER), a broadly expressed G protein–coupled receptor that ...

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States ...