Anthrax, an infectious disease caused by the bacterium Bacillus anthracis, is often treatable in its early stages. But once ...

University of Pittsburgh researchers discovered that a mix of growth factors can rescue cells from late-stage anthrax damage ...

Results provide proof-of-concept that ERK pathway reactivation might be an effective, biologically based therapy to prevent anthrax-induced lethality.

Anthrax, an infectious disease caused by the bacterium Bacillus anthracis, is often treatable in its early stages. But once ...

These included MEK1 and MEK2, which control a pathway called ERK involved in cellular division and survival, and MEK3 and MEK6, which regulate the p38 pathway that's involved in stress-induced ...

Outside of thrash metal circles, anthrax is treated with deadly seriousness. Caused by the bacterium Bacillus anthracis, this ...

Verastem (NASDAQ:VSTM – Get Free Report) and Nurix Therapeutics (NASDAQ:NRIX – Get Free Report) are both small-cap medical ...

来自国际顶尖团队的研究人员针对炭疽致死毒素 (LT)引发MEKs蛋白水解失活、导致ERK/p38/JNK信号通路中断的致命机制，创新性构建了抗蛋白酶解的MEK2 (P10V/A11D)、MEK3 (I27D)和MEK6 (I15D)突变体。转基因小鼠实验证实，这些突变体可维持ERK/p38通路持续激活，显著提升宿主细胞在LT或炭疽杆菌攻击下的存活率，为毒素内化后的靶向治疗开辟新途径。