This was accompanied by an impairment of mitochondrial function with reduced expression of carnitine palmitoyltransferase I and an induction of acyl-coenzyme A oxidase-1 (ACOX1), oxidative stress and ...

We thank Professor John L. Rubenstein for his comments, suggestions, and edits. We are grateful to Professor Hua Han for sharing the Rbpj floxed mice, and Professor Jean M. Hebert for sharing ...

Furthermore, SOCS3 silencing resulted in a decrease in the IL-1β-stimulated expression of phosphorylated- and total- ERK, p38, and JNK in GO fibroblasts (Figure 5). In normal fibroblasts, the ...

Mechanistically, we observed an increase of p38 phosphorylation and subsequent downregulation of GATA1 after CCL3 treatment. Furthermore, knockdown of CCL3 attenuated leukemic progression and ...

One of the key players in mediating pro-inflammatory signaling is the Janus Kinase (JAK) 1/2. Signaling via JAK1/2 and signal transducer and activator of transcription (STAT) pathways are crucial for ...

The cardiovascular system is a highly complex, well organised system in which signal transduction plays critical physiological and pathophysiological roles. The cellular elements of the heart and ...

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois 60611, United States Division of Hematology and Oncology, Department of Medicine, Feinberg School of Medicine, ...

Objective Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in ...

The scaffold protein JIP1 plays a key role in the c-Jun N-terminal kinase (JNK) signaling pathway by facilitating the colocalization of multiple kinases, thereby ensuring their precise and efficient ...

College of Animal Sciences, Zhejiang University, Hangzhou, China Key Laboratory of Molecular Animal Nutrition (Zhejiang University), Ministry of Education, China Key Laboratory of Animal Feed and ...

Principal is the amount you borrowed, and interest is the amount you pay to the lender as a charge for borrowing. To calculate interest, multiply the principal amount by the interest rate, then ...