这项新研究的核心是称为毒性外显子（poison exon）的微小遗传元件，这是大自然自己的蛋白生产“开关”。当这些外显子包含在RNA信息中时，它们会在蛋白形成之前触发其破坏，从而防止有害的细胞活动。在健康细胞中，毒性外显子调节关键蛋白的水平，控制遗传机制。但在癌症中，这种安全机制经常失效。

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Natural "off switch" could slow or even reverse the growth of aggressive tumors.

Alternative RNA splicing is like a movie editor cutting and rearranging scenes from the same footage to create different ...

Cells have a natural editing system that allows them to rearrange genetic instructions to create different proteins from the ...

Scientists reveal how cancer cells manipulate RNA splicing, increasing tumor growth. A new study introduces antisense ...

Researchers have discovered that cancer cells suppress 'poison exons' -- genetic elements that act as an off switch for protein production -- in a key gene called TRA2 , promoting tumor growth. By ...

A study reveals how cancer disrupts RNA splicing and presents a potential therapy using antisense oligonucleotides to target ...

Breakthrough discovery in cancer research! Scientists uncover a simple genetic strategy to combat aggressive cancers. Learn ...

They found their answer in antisense oligonucleotides (ASOs)-synthetic RNA fragments that can be designed to increase poison exon inclusion in specific ways. When introduced into cancer cells ...

Avidity Biosciences (RNA) announced del-zota topline data from the Phase 1/2 EXPLORE44 trial in people living with Duchenne muscular dystrophy ...

Avidity Biosciences (RNA) announced positive del-zota topline data from the Phase 1/2 EXPLORE44 trial in people living with Duchenne muscular ...