Tyra Biosciences' TYRA-300, an oral FGFR3 inhibitor, showed promising efficacy but raised concerns with some FGFR1/2-driven adverse events, causing a significant stock drop. TYRA-300 demonstrated ...

Researchers have identified in a new study that oral infigratinib, an FGFR1-3 selective tyrosine kinase inhibitor, improves ...

Tasurgratinib (also known as E-7090) is an oral selective FGFR1, FGFR2, and FGFR3 inhibitor that, if approved, will join other drugs in the class on the market, including Incyte’s Pemazyre ...

Tyra Biosciences, Inc. (Nasdaq: TYRA), a clinical-stage biotechnology company focused on developing next-generation precision ...

Objective Sodium–glucose cotransporter 2 (SGLT-2) inhibitors are the most recently approved antihyperglycemic medications. We sought to describe their association with euglycemic diabetic ...

The authors provide convincing evidence indicating that two receptor tyrosine kinases (RTKs), CAD96CA and FGFR1, modulate the genomic effects of JH by phosphorylating the intracellular receptors in ...

The FGFR family comprises four members, FGFR1-4, which are highly conserved tyrosine kinase transmembrane receptors ... Although the development of tyrosine kinase activity inhibitors has been ...

研究人员针对垂体肿瘤开展研究，发现 FGFR1 D129A 变异或与垂体肿瘤发生有关，意义重大。 探索垂体疾病的遗传奥秘：FGFR1 变异的关键作用 在人体内分泌系统中，垂体犹如一个 “指挥官”，它分泌的多种激素对生长、发育、代谢等生命活动起着至关重要的调节 ...

In this important study, Li and others identified cell membrane receptors for juvenile hormone (JH), a terpenoid hormone in insects that regulates their development and reproduction. While ...