Seven-transmembrane receptors (7TMRs), also known as G protein-couple receptors, are the largest class of transmembrane receptors and a common target for therapeutics. Initially thought to signal ...

GLP-1 receptor agonists are pharmaceutical treatments primarily for T2D and more recently, obesity. They function by mimicking the action of GLP-1 hormone, which plays a crucial role in ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

A breach in the gut immunity and crossreactivity of the IgE antibodies with skin antigens or direct interaction with specific IgE, Fc receptors ... specific IgE binds to FcRI on tissue-resident ...

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New genetic risk score identifies individuals at risk for heart disease who may benefit most from cholesterol-lowering therapies Date: February 26, 2025 Source: Mass General Brigham Summary ...

Specifically, Auletta highlights the emerging science in stem cell transplants and cell therapies, including treatments like chimeric antigen receptor (CAR) T-cell therapy. He also discussed topics ...

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

Piperine stimulates the pain receptors of rats and other mammals, causing them to sneeze, cough, and "scurry away." A cluttered space is an ideal habitat for a rat, especially in garages where ...