we identified dynamic changes in novel subsets of fibroblasts during morphogenesis and resolved a putative differentiation hierarchy emanating from CD34 hi mesenchymal progenitor cells. Perturbation ...

This review discusses the diversity and heterogeneity of fibroblasts in secondary lymphoid organs such as lymph nodes, spleen, and Peyer’s patches, and their contributions to a range of pathological ...

In this study, we apply single-cell sequencing to investigate the role of the GEM gene in SLE. GEM, a GTPase involved in cellular processes such as fibroblast differentiation, has been implicated in ...

Pin1 plays a pivotal role in regulating cellular processes including growth and differentiation by catalyzing the cis-trans isomerization ... Recent studies have identified Pin1 as a driver of ...

Concept: Epithelial JAG1–NOTCH1 signaling promotes the transformation of normal fibroblasts into CAFs. Impact: Assessing epithelial differentiation and stromal-immune alterations may help track SCC ...

In contrast, activation of VDR by paricalcitol reduced the stimulatory effects of TGF-β on fibroblasts and inhibited collagen release and myofibroblast differentiation. Paricalcitol stimulated the ...

To determine whether Piezo2 signaling is required for stiffness-driven myofibroblast differentiation, the team cultured human lung fibroblasts on substrates of increasing stiffness with or without ...

A recent publication in Genes & Diseases has delivered a compelling synthesis of the latest insights into the cellular ...

Focusing on Grb2 – a protein that is essential for activating Ras-MAPK signaling – Wang et al. showed that deleting the gene for Grb2 leads to defects in fiber cell differentiation but not early lens ...

BPC-157, a pentadecapeptide derived from an endogenously occurring protein sequence in gastric juice, has garnered attention ...