Disrupting cancer fitness and pro-tumorigenic fibroblast functions with a first-in-class Pin1 degrader [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; ...

Fibroblasts are cells of mesenchymal origin with a range of phenotypic diversity and heterogeneity. One of the major functions of fibroblasts is the formation and turnover of the extracellular matrix ...

New research demonstrates the role of the Galectin-1 protein in the nucleus of the cells surrounding the tumor-fibroblasts ...

This longitudinal single-cell transcriptome atlas examines global changes amongst murine mammary gland fibroblasts during normal development and oncogenesis across seven different states, revealing a ...

Now, we may know why zombie skin cells have this double agent-esque existence. Not all senescent skin cells are the same.

Researchers from Johns Hopkins University have identified three subtypes of senescent skin cells with distinct shapes, ...

Pancreatic cancer is one of the most aggressive cancers and has one of the lowest survival rates—only 10% after five years.

Recent research has proposed that the GEM gene may regulate fibroblast activity in SLE. However, the precise molecular mechanisms through which GEM modulates fibroblast functions in the context of SLE ...

Not all zombie skin cells are the same. New research reveals three unique subtypes with different roles in aging and disease, ...