Hepatic fibrosis is a reversible wound healing response characterized by accumulation of extracellular matrix (ECM), or "scar," that follows chronic but not self-limited liver disease. The ECM ...

A comprehensive proteomic map of liver fibrosis progression and healing in two mouse models identifies etiology-specific extracellular matrix components, laying the foundation for targeted ...

Piezo2 is increased in idiopathic pulmonary fibrosis (IPF). Immunohistochemistry of nonfibrotic (left) and IPF (right) lung tissue demonstrating that Piezo2 (brown staining) is strongly present in ...

The new study in The American Journal of Pathology, published by Elsevier ... Idiopathic pulmonary fibrosis (IPF) is a devastating progressive fibrotic lung disease with a median survival of ...

When Katherine Stueland was 11 years old, she went to a reunion for her mother’s branch of the family tree and learned that multiple cousins had cystic fibrosis. Stueland didn’t know what it meant for ...

Major discrepancies are seen with the use of noninvasive tests compared with liver biopsy in a posttransplant setting.

More information: Margaret A.T. Freeberg et al, Piezo2 Is a Key Mechanoreceptor in Lung Fibrosis that Drives Myofibroblast Differentiation, The American Journal of Pathology (2025). DOI ...

The findings emphasize the importance of exosomal lncRNAs, which function as molecular regulators in kidney pathology and hold ... ultimately resulting in renal fibrosis and organ failure.

Blocking Piezo2, a protein receptor that senses mechanical forces in tissues, may be a new way to slow IPF progression, per a ...