Filopodia are specialized structures that extend from the cell membrane to allow a cell to explore the environment around it. These thin protrusions are full of a protein called actin, which, in ...

To move, these migratory cells rely on filopodia—sensitive, finger-like protrusions that reach out from the cell membrane into the local environment. In a healthy cell, this can be a lifesaver ...

Computer simulations of filopodia dynamics indicate that a rotating actin structure inside the tube results in friction between the membrane and the actin, leading to the spiral form that is observed.

Tip cell filopodia express high-affinity tyrosine kinase receptors for VEGF, which dimerize and autophosphorylate upon ligand binding. VEGF receptor activation promotes its internalization and the ...