其突破性成果的核心在于：通过化学设计策略在单一分子内实现对相关G蛋白偶联受体（G-protein coupled receptors, GPCRs）的协同激活，创新性地将GLP-1和GIP两种促胰岛素的作用整合至一个单分子中，通过同时激活这两个受体，从而显著降低血糖水平。这些创新性多肽 ...

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P. R. China School of Environment, ...

These findings have uncovered previously unknown histone deacetylase complex subunits and highlighted an angiosperm-specific feature of the SIN3-type histone deacetylase complex, which is crucial for ...

mGluRs 属于 G 蛋白偶联受体（GPCRs）中的 C 类，以二聚体形式存在，包括同源二聚体和异源二聚体，在神经系统的突触传递和可塑性方面发挥着核心作用。它们如同精密的 “信号开关”，对谷氨酸的响应多样，具有不同的配体亲和力、功效和动力学特征。然而 ...

In this article, we are going to take a look at where Structure Therapeutics Inc. (NASDAQ:GPCR) stands against other promising small-cap stocks. Robert Teeter of Silvercrest Asset Management ...

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, ...

在人体中，46 种趋化因子（chemokine）与 23 种 G 蛋白偶联受体（GPCR）的相互作用协调细胞迁移，但其选择性和 promiscuity 的分子机制不明。研究人员通过整合多种数据，明确了相关识别元件。这有助于设计新型免疫疗法和细胞疗法，为相关疾病治疗提供新思路。

The researchers analyzed chemokines and their associated G protein-coupled receptors (GPCRs), proteins that govern cell movement. They found that specific positions within structured and ...