snu.ac.kr Objective Endoplasmic reticulum (ER) stress is involved in liver injury, but molecular determinants are largely unknown. This study investigated the role of pleckstrin homology-like domain, ...

Disruption of ER function can trigger unfolded protein response (UPR), which is activated by ER stress (ERS). In this study ... Specially, the expression of glucose-regulated protein 78 (GRP78) was ...

Protein aggregates are spatially organized and regulated in cells to prevent deleterious effects of proteostatic stress. Misfolding of proteins in the ER result in aggregate formation, but how the ...

Physician and Author of The Stress Paradox: Why You Need Stress to Live Longer, Healthier, and Happier Physician and Author of The Stress Paradox: Why You Need Stress to Live Longer, Healthier ...

Can stress cause a seizure? This is a question that many people with epilepsy ask when searching for potential seizure triggers. While the exact reason why stress can cause seizures for some people is ...

As a stress hormone, CORT levels fluctuate with the degree and duration of ... while the anti-inflammatory factor IL-10 activates the anti-apoptotic pathway. This dual signaling in the ER triggers ERS ...

Stress can trigger an asthma attack. While there is no cure for asthma, there are ways to manage both the symptoms and the stress itself. Asthma is a chronic lung disease. The airways of people ...

Stress is a natural reaction to specific demands and events, but ongoing stress can affect a person’s health and wellbeing. Tips for managing stress include exercise, setting priorities ...

Early life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

胶质母细胞瘤（GB）侵袭性强、对标准治疗反应差。为探索新疗法，研究人员以浅蓝菌素（CER）抑制脂肪酸合酶（FASN）开展研究。结果发现，CER 可抑制 GB 细胞增殖、迁移，诱导细胞凋亡等。该研究为 GB 治疗提供新方向。