为改善肾透明细胞癌（ccRCC）患者预后，研究人员构建 RHO-GTPase 基因风险模型，成果意义重大。 肾透明细胞癌（clear cell renal cell carcinoma，ccRCC）作为肾癌中最常见的亚型，一直是医学界的 “硬骨头”。它就像一个隐藏在身体里的 “狡猾敌人”，预后状况常常 ...

Rapid activation of adenosine monophosphate-activated protein kinase (AMPK) induces phosphorylation of mitochondrial-associated proteins, a process by which phosphate groups are added to regulate ...

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Objective To monitor trastuzumab resistance and determine the underlying mechanisms for the limited response rate and rapid emergence of resistance of HER2+ metastatic gastric cancer (mGC). Design ...

Albert Ong is Professor of Renal Medicine at the University of Sheffield, UK. He studied medicine at the University of Oxford and trained as a clinician-scientist at University College London and ...

Next-generation sequencing (NGS) detected multiple clinically significant variants, including MSH2, NF1, MTOR, PTEN, TSC2, ATRX, TP53, MUTYH and RB1. No pathogenic variants were seen in BRAF, IDH1, ...