The TSC complex, consisting of TSC1 and TSC2, interacts with GTPase-Ras to serve as a negative regulator of mTOR activity. When TSC2 is phosphorylated by kinases (such as AKT), it dissociates from the ...

Rapid activation of adenosine monophosphate-activated protein kinase (AMPK) induces phosphorylation of mitochondrial-associated proteins, a process by which phosphate groups are added to regulate ...

Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao 266003, P. R. China Qingdao Key Laboratory of Thyroid, Diseases, Medical Research Center, Qingdao 266555, ...