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氯胺酮抗抑郁新机制:精准调控伏隔核 D1-MSNs 突触功能改善快感缺失
伏隔核(NAc)是大脑奖赏回路的关键组成部分,主要包含表达 D1 或 D2 多巴胺受体的 GABA 能中等棘状神经元(MSNs),即 D1 - MSNs 和 D2 - MSNs。NAc 在奖赏和动机行为中起重要作用,且对慢性应激敏感,其 MSN 生理和功能在慢性应激后会发生亚型特异性变化。临床研究 ...
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