and it will also work on a metabotropic glutamate receptor subtype 7 negative allosteric modulator (NAM). Both are in preclinical development. Other companies working on PAMs include Cerevel ...

National Academy of Sciences National Academy of Engineering National Academy of Medicine ...

Nitric oxide (NO) is a gaseous signalling molecule that is involved in the regulation of the cardiovascular, immune and nervous systems. In the CNS, NO is involved in many processes, including the ...

The cash will be used to support two phase 2 trials of TMP-301, a metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator (NAM), in people battling alcohol and cocaine use disorders.

In this important study, the authors use computational modeling to explore how rapid learning can be reconciled with the accumulation of stable memories in the olfactory bulb, where adult neurogenesis ...